The two fierce rivals will play out their first Clasico at Camp Nou just two months into the league season, with the return fixture scheduled for early March.
The fixtures for the 2012-13 Liga season have been released, revealing the dates for the two Clasico clashes between Real Madrid and Barcelona.
The Blaugrana will entertain Los Blancos in the league season's first Clasico at home on October 7, with the return fixture taking place at the Santiago Bernabeu on March 3.
The competition will commence on August 18 and will run through to June 1, with just the penultimate round of the scheduled 38 to take place during midweek.
The final dates of the tournament may of course be altered should Madrid, Barcelona, Valencia or Malaga reach the latter stages of the Champions League.
Reigning champions Madrid begin their campaign at home to Valencia while Barcelona will entertain Real Sociedad at Camp Nou.
Barcelona Real Sociedad
Real Madrid Valencia
Athletic Bilbao Real Betis
Atletico Madrid Levante
Real Zaragoza Valladolid
Celta Vigo Malaga
Rayo Vallecano Granada
Deportivo La Coruna Osasuna